関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 1-Phenyl-cyclopropylamine | HCID 194549 | — |
| 反応物 | 4,6-Dichloronicotinamide | HCID 600044 | — |
| 溶媒 | 2-Oxopropiononitrile | HCID 69430 | — |
| 生成物 | 6-Chloro-4-(1-phenylcyclopropylamino)nicotinamide | HCID 86664541 | 36.5% |
反応手順
To a suspension of 4,6-dichloronicotinamide (191 mg, 1 mmol) in AcCN (2 mL) was added 1-phenylcyclopropanamine (160 mg, 1.2 mmol) and DIPEA (0.213 mL, 1.2 mmol). The mixture was heated at 60° C. for 2 days. The mixture was concentrated and purified by column chromatography to give 6-chloro-4-(1-phenylcyclopropylamino)nicotinamide (105 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09102625B2 |
|---|
| 出典データセット | uspto-grants-2015_08 |
|---|
| ORD ID | ord-bf1fb13d2bfd4e1ab3635b34fda50fdf |
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| 出典メモ | uspto-grants-2015_08 |
|---|
