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Tert-butyl 4-(3-nitrophenyl)piperazine-1-carboxylate → tert-Butyl 4-(3-aminophenyl)piperazine-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tert-butyl 4-(3-nitrophenyl)piperazine-1-carboxylate | HCID 22330126 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | tert-Butyl 4-(3-aminophenyl)piperazine-1-carboxylate | HCID 22330182 | — |
反応手順
To a solution of tert-butyl 4-(3-nitrophenyl)piperazine-1-carboxylate in EtOH (20 mL) and THF (10 mL) was added Pd/C (500 mg), the mixture was charged with H2 (1 atm) and stirred for 16 h. Pd/C was filtered off, the filtrate was concentrated to give tert-butyl 4-(3-aminophenyl)piperazine-1-carboxylate (1.71 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09102625B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-1ed4b68bf7e8475f86a60a9f5e6fa90a |
| 出典メモ | uspto-grants-2015_08 |