関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 3-Iodobenzylamine | HCID 97012 | — |
| 反応物 | 4,6-Dichloronicotinamide | HCID 600044 | — |
| 溶媒 | 2-Oxopropiononitrile | HCID 69430 | — |
| 生成物 | 6-Chloro-4-(3-iodobenzylamino)nicotinamide | HCID 86664546 | 97.9% |
反応手順
To a solution of 4,6-dichloronicotinamide (296 mg, 1.55 mmol) in AcCN (3 mL) was added 3-iodobenzylamine (396 mg, 1.70 mmol) and DIPEA (0.383 mL, 2.32 mmol). After stirring at 80° C. for 15 h, the mixture was concentrated and added water, the resulting precipitate was collected by filtration to give 6-chloro-4-(3-iodobenzylamino)nicotinamide (588 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09102625B2 |
|---|
| 出典データセット | uspto-grants-2015_08 |
|---|
| ORD ID | ord-cb633a02535342f488c2c115d7203c4b |
|---|
| 出典メモ | uspto-grants-2015_08 |
|---|
