2-(Tributylstannyl)pyridine → Tert-butyl-3-(pyridin-2-yl)benzylcarbamate

HRID 513293

反応式

HRID 513293 の反応式
[C:1]([O:5][C:6](=[O:16])[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11](I)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].C([Sn](CCCC)(CCCC)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=1)CCC>O1CCOCC1.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[C:1]([O:5][C:6](=[O:16])[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=2)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

5

反応物 2

HCID 6077842-(Tributylstannyl)pyridineHCID 11645663tert-Butyl 3-iodobenzylcarbamate

生成物 1

HCID 69029928Tert-butyl-3-(pyridin-2-yl)benzylcarbamate収率 78.1%

試薬・触媒・溶媒 2

HCID 178418397HCID 178418397、化合物触媒HCID 312751,4-Dioxane溶媒

反応条件

温度
100 °C

実験手順

To a solution of tert-butyl-3-iodobenzylcarbamate (166 mg, 0.50 mmol) in Dioxane (1.5 mL) was added Pd(PPh3)4 (58 mg, 0.05 mmol) and 2-(tributylstannyl)pyridine (275 mg, 0.75 mmol). After stirring at 100° C. for 2 h, it was concentrated and the residue was purified by column chromatography to give tert-butyl-3-(pyridin-2-yl)benzylcarbamate (111 mg).

後処理

  1. concentrationit was concentrated
  2. customthe residue was purified by column chromatography

出典と根拠

ORDレコード
ord-e72f51f70e1d4e489c74252f62880107
出典データセット
uspto-grants-2015_08
特許番号
US09102625B2

関連ノート

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