関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 8-Methoxy-3-methylquinoline | HCID 13984286 | — |
| 溶媒 | Hydrogen Bromide | HCID 260 | — |
| 生成物 | 3-Methylquinolin-8-ol | HCID 4332281 | 83% |
反応手順
47% HBr (10 ml) was added to 8-methoxy-3-methylquinoline (Intermediate 29) (500 mg, 2.80 mmol) and heated at 122° C. for 18 h. The reaction was cooled to room temperature, the pH adjusted with sodium carbonate solution to pH=7 and extracted with DCM. The organic phase was dried (Na2SO4) and concentrated in vacuo to give the title compound (150 mg, 83%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09102688B2 |
|---|
| 出典データセット | uspto-grants-2015_08 |
|---|
| ORD ID | ord-c3d07f806a224b27afb62b8d2a4d5e6f |
|---|
| 出典メモ | uspto-grants-2015_08 |
|---|
