化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → 3-Methyl-8-quinolinamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Ammonium Sulfite | HCID 25041 | — |
| 反応物 | 3-Methylquinolin-8-ol | HCID 4332281 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-Methyl-8-quinolinamine | HCID 15783794 | 91.3% |
反応手順
3-methylquinolin-8-ol (Intermediate 30) (150 mg, 0.9 mmol) and ammonium sulphite (250 mg, 1.8 mmol) were added to aqueous ammonia (3 ml) and heated for 48 h. After cooling, water was added and the mixture was extracted with DCM. The organic phase was dried (Na2SO4) and concentrated in vacuo to give the title compound (130 mg, 86%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09102688B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-deb45c358e1b499eb3e02cc0c03b2144 |
| 出典メモ | uspto-grants-2015_08 |