Stannous Chloride → 5-Methylquinolin-8-amine
反応式
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.[Sn](Cl)Cl>Cl>[CH3:1][C:2]1[CH:11]=[CH:10][C:9]([NH2:12])=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2参加物
4
実験手順
In a similar fashion using route 1 general procedure 4, 5-methyl-8-nitroquinoline (Intermediate 32) (950 mg, 5.05 mmol), tin (II) chloride (2.87 g, 15.1 mmol) and 6 N HCl (5 drops) gave the title compound (950 mg, >100% crude) which was used in the next step without purification. The structure was confirmed by 1H NMR.
出典と根拠
- ORDレコード
- ord-5e1443f4b070423888d2b5cf1fb5e649
- 出典データセット
- uspto-grants-2015_08
- 特許番号
- US09102688B2
反応ノート
読み込み中…