化工社化工社 化学情報印刷レポート · 研究参考用
Stannous Chloride → 8-Quinolinamine, 5-(trifluoromethyl)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Stannous Chloride | HCID 24479 | — |
| 反応物 | 8-Nitro-5-(trifluoromethyl)quinoline | HCID 68183100 | — |
| 触媒 | Hydrochloric Acid | HCID 313 | — |
| 生成物 | 8-Quinolinamine, 5-(trifluoromethyl)- | HCID 10353118 | 85.5% |
反応手順
In a similar fashion using route 1 general procedure 4, 8-nitro-5-(trifluoromethyl)quinoline (Intermediate 33) (820 mg, 3.39 mmol), tin (II) chloride (1.93 g, 10.2 mmol) and 6 N HCl (10 drops) gave the title compound (615 mg, 85%) which was used in the next step without purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09102688B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-975e25dcd1ed40b6afd70c4f19df1dfd |
| 出典メモ | uspto-grants-2015_08 |