Stannous Chloride → 6-Ethoxyquinolin-8-amine
反応式
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]2[C:11](=[C:12]([N+:14]([O-])=O)[CH:13]=1)[N:10]=[CH:9][CH:8]=[CH:7]2)[CH3:2].[Sn](Cl)Cl>Cl>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]2[C:11](=[C:12]([NH2:14])[CH:13]=1)[N:10]=[CH:9][CH:8]=[CH:7]2)[CH3:2]参加物
4
実験手順
In a similar fashion using route 1 general procedure 4, 6-ethoxy-8-nitroquinoline (Intermediate 35) (900 mg, 4.12 mmol), tin (II) chloride (2.4 g, 12.4 mmol) and 6 N HCl (10 drops) gave the title compound (700 mg, 90%) which was used in the next step without purification.
出典と根拠
- ORDレコード
- ord-91a61343ff3e4467ac0fedd488f87839
- 出典データセット
- uspto-grants-2015_08
- 特許番号
- US09102688B2
反応ノート
読み込み中…