Stannous Chloride → 5-Fluoroquinolin-8-amine

HRID 513402ノート

反応式

HRID 513402 の反応式
[F:1][C:2]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.[Sn](Cl)Cl>Cl>[F:1][C:2]1[CH:11]=[CH:10][C:9]([NH2:12])=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2

参加物

4

反応物 2

HCID 24479Stannous ChlorideHCID 1539725-Fluoro-8-nitroquinoline2 回

生成物 1

HCID 445582645-Fluoroquinolin-8-amine収率 106.7%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid触媒

実験手順

In a similar fashion using route 1 general procedure 4, 5-fluoro-8-nitroquinoline (Intermediate 38) (500 mg, 2.60 mmol), tin (II) chloride (1.48 mg, 7.80 mmol) and 6N HCl (4 drops) gave the title compound (450 mg, >100% crude) which was used in the next step without purification. The structure was confirmed by 1H NMR.

出典と根拠

ORDレコード
ord-298ae85fea2e40198d3e3363f146e7b2
出典データセット
uspto-grants-2015_08
特許番号
US09102688B2

反応ノート

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