化工社化工社 化学情報印刷レポート · 研究参考用
Benzenesulfonyl chloride → N-(2-methylquinolin-8-yl)benzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzenesulfonyl chloride | HCID 7369 | — |
| 反応物 | 2-Methyl-8-aminoquinoline | HCID 140457 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 生成物 | N-(2-methylquinolin-8-yl)benzenesulfonamide | HCID 2848041 | 43% |
反応手順
In the similar fashion using route 14 general procedure 27, 2-methyl-8-aminoquinoline (Intermediate 22) (200 mg, 1.2 mmol), benzenesulfonyl chloride (230 mg, 1.2 mmol) and DMAP (cat.) gave the title compound (150 mg, 43%) after purification by column chromatography with DCM as the eluent.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09102688B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-e2a79950bf3740699f7a9a2b8d9a89f0 |
| 出典メモ | uspto-grants-2015_08 |