Benzenesulfonyl chloride → HCID 60164004、化合物

反応式

[Cl:1][C:2]1[C:11]([CH3:12])=[CH:10][C:9]([NH2:13])=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.[C:14]1([S:20](Cl)(=[O:22])=[O:21])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>CN(C1C=CN=CC=1)C>[Cl:1][C:2]1[C:11]([CH3:12])=[CH:10][C:9]([NH:13][S:20]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)(=[O:22])=[O:21])=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2

参加物

実験手順

In a similar fashion using route 14 general procedure 27, 5-chloro-6-methylquinolin-8-amine (Intermediate 51) (160 mg, 0.83 mmol), benzenesulfonyl chloride (175 mg, 0.99 mmol) and DMAP (cat.) gave the title compound (110 mg, 40%) after purification by column chromatography with n-hexane/EtOAc (1:1), followed by DCM/MeOH (99:1) as the eluent.