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Pyridine → Pyridine-2-sulfonic acid (5-trifluoromethyl-quinolin-8-yl)-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Pyridine-2-sulfonyl Chloride | HCID 3787675 | — |
| 反応物 | 8-Quinolinamine, 5-(trifluoromethyl)- | HCID 10353118 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Pyridine-2-sulfonic acid (5-trifluoromethyl-quinolin-8-yl)-amide | HCID 60164194 | 31.7% |
反応手順
In a similar fashion using route 14 general procedure 27, 5-trifluoromethyl-quinolin-8-ylamine (Intermediate 45) (125 mg, 0.58 mmol), pyridine-2-sulfonyl chloride (Intermediate 18) (125 mg, 0.70 mmol), pyridine (0.09 ml, 1.17 mmol), DMAP (cat.) and DCM (5 ml) gave the title compound (65 mg, 31%) after purification by column chromatography with n-hexane/DCM (50:50) as the eluent.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09102688B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-d0e2902fa3b040c2a9cfb93694e09d45 |
| 出典メモ | uspto-grants-2015_08 |