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Pyridine → 3-Nitro-pyridine-2-sulfonic acid quinolin-8-ylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | 8-Aminoquinoline | HCID 11359 | — |
| 反応物 | 3-Nitropyridine-2-sulfonyl chloride | HCID 54328841 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-Nitro-pyridine-2-sulfonic acid quinolin-8-ylamide | HCID 68183280 | 42% |
反応手順
In a similar fashion using route 14 general procedure 27, 8-aminoquinoline (1.3 g, 9.36 mmol), 3-nitro-pyridine-2-sulfonyl chloride 445 (2.7 g, 12.2 mmol), pyridine (2.25 ml, 28.1 mmol), DMAP (cat.) and DCM (100 ml) gave the title compound (1.3 g, 42%) after purification by column chromatography with DCM as the eluent.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09102688B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-051dbd3e7d654674b958a518d5ed6c11 |
| 出典メモ | uspto-grants-2015_08 |