Stannous Chloride → HCID 86669762、化合物
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[CH:13]=[CH:14][CH:15]=[C:16]3[C:21]=2[N:20]=[C:19]([Cl:22])[CH:18]=[CH:17]3)(=[O:10])=[O:9])=[C:4]([N+:23]([O-])=O)[CH:3]=1.Cl[Sn]Cl>CCO>[NH2:23][C:4]1[CH:3]=[C:2]([Cl:1])[CH:7]=[CH:6][C:5]=1[S:8]([NH:11][C:12]1[CH:13]=[CH:14][CH:15]=[C:16]2[C:21]=1[N:20]=[C:19]([Cl:22])[CH:18]=[CH:17]2)(=[O:9])=[O:10]参加物
4
実験手順
In a similar fashion using route 1 general procedure 4, 4-chloro-N-(2-chloro-quinolin-8-yl)-2-nitro-benzenesulfonamide (Intermediate 258) (0.36 g, 0.63 mmol), SnCl2 (0.36 g, 1.88 mmol) and EtOH (10 ml) at 90° C. for 4 h gave the title compound (0.11 g, 46%) after purification by column chromatography with DCM/MeOH (99.5:0.5) as the eluent.