化工社化工社 化学情報印刷レポート · 研究参考用
Sodium borohydride → 2-Methyl-1,4-dihydro-2H-3-thia-2,4,5-triaza-phenanthrene 3,3-dioxide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | 8-Aminoquinoline-7-carboxaldehyde | HCID 11052098 | — |
| 反応物 | N-Methylsulfamoyl chloride | HCID 11789235 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 2-Methyl-1,4-dihydro-2H-3-thia-2,4,5-triaza-phenanthrene 3,3-dioxide | HCID 68183210 | 14% |
反応手順
In a similar fashion using route 27 general procedure 70, 8-amino-quinoline-7-carbaldehyde (100 mg, 0.58 mmol), N-methylsulfamoyl chloride (226 mg, 1.74 mmol), NaBH4 (22 mg, 0.58 mmol) and pyridine (1 ml) gave the title compound (20 mg, 14%) after purification by column chromatography with heptane/EtOAc (90:10) as the eluent.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09102688B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-886fe303358d4e579d762fe2c7ef976d |
| 出典メモ | uspto-grants-2015_08 |