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8-Aminoquinoline-7-carboxaldehyde → 1-(8-Amino-quinolin-7-yl)-propan-1-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 8-Aminoquinoline-7-carboxaldehyde | HCID 11052098 | — |
| 反応物 | HCID 178418443 | HCID 178418443 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 1-(8-Amino-quinolin-7-yl)-propan-1-ol | HCID 68183160 | 91% |
反応手順
In a similar fashion using route 27 general procedure 66, 8-amino-quinoline-7-carbaldehyde 404 (1 g, 5.83 mmol), ethyl magnesium bromide (3M in THF; 5.81 ml, 17.44 mmol) and THF (30 ml) gave the title compound (900 mg, 91%) after purification by column chromatography with DCM/MeOH (99:1) as the eluent.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09102688B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-b95d17859f234fef9834127523f43a6a |
| 出典メモ | uspto-grants-2015_08 |