化工社化工社 化学情報印刷レポート · 研究参考用
Water → 4-Fluoro-5-methyl-2-nitro-benzenesulfonic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium Sulfite | HCID 24437 | — |
| 反応物 | 1,4-Difluoro-2-methyl-5-nitrobenzene | HCID 230658 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-Fluoro-5-methyl-2-nitro-benzenesulfonic acid | HCID 86669766 | 73.6% |
反応手順
In a similar fashion using route 39 general procedure 95, 1,4-difluoro-2-methyl-5-nitrobenzene (1.2 g, 6.93 mmol) in EtOH (10 ml) and Na2SO3 (1.98 g, 15.7 mmol) in EtOH:water (40 ml:25 ml) at 70° C. for 16 h gave the title compound (1.2 g, 73%) which was used in the next step without purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09102688B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-51c1a3014a69401fa6314e5f4b249712 |
| 出典メモ | uspto-grants-2015_08 |