HCID 68190304、化合物 → HCID 68190292、化合物
反応式
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]([C:17]2[CH:34]=[C:33]3[C:20]([S:21](=[O:37])(=[O:36])[NH:22][C:23]4[C:32]3=[CH:31][C:30]([Cl:35])=[C:29]3[C:24]=4[N:25]=[CH:26][CH:27]=[CH:28]3)=[CH:19][CH:18]=2)=[O:16])[CH2:10][CH2:9]1)=O)(C)(C)C>Cl.O1CCOCC1>[NH:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]([C:17]2[CH:34]=[C:33]3[C:20]([S:21](=[O:37])(=[O:36])[NH:22][C:23]4[C:32]3=[CH:31][C:30]([Cl:35])=[C:29]3[C:24]=4[N:25]=[CH:26][CH:27]=[CH:28]3)=[CH:19][CH:18]=2)=[O:16])[CH2:10][CH2:9]1参加物
4
実験手順
A solution of 12-chloro-6,6-dioxo-5,6-dihydro-6λ*6*-thia-4,5-diaza-chrysene-9-carboxylic acid 1-tert-butoxycarbonyl-piperidin-4-yl ester 534 (70 mg, 0.12 mmol) in 4M HCl in dioxane (3 ml) was stirred at room temperature for 12 h. The solvent was removed in vacuo and the residue was washed with MeOH to give the title compound (27 mg, 47%).