[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl[C:8]1[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[C:14]2[C:9]=1[CH:10]=[CH:11][CH:12]=[N:13]2>CS(C)=O.O>[N:1]1([C:8]2[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[C:14]3[C:9]=2[CH:10]=[CH:11][CH:12]=[N:13]3)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1Morpholine (251.6 μl, 2.88 mmol) was added to a solution of 5-chloro-8-nitro-quinoline 27 (200 mg, 0.96 mmol) in DMSO (2 ml) and the mixture was heated at 100° C. in a sealed tube for 18 h. After cooling, the mixture was diluted with water (10 ml) and the resulting precipitate was collected by filtration. The solid was dried in vacuo to give the title compound (200 mg, 81%) which was used in the next step without further purification.
読み込み中…
