Hydrochloric Acid → HCID 178432279、化合物

HRID 513867

反応式

HRID 513867 の反応式
[ClH:1].C(=[N:15][NH:16][C:17]1[CH:26]=[C:25]([F:27])[C:20]2[NH:21][C:22]([CH3:24])=[N:23][C:19]=2[CH:18]=1)(C1C=CC=CC=1)C1C=CC=CC=1>C(O)C>[ClH:1].[ClH:1].[F:27][C:25]1[C:20]2[NH:21][C:22]([CH3:24])=[N:23][C:19]=2[CH:18]=[C:17]([NH:16][NH2:15])[CH:26]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 178432276HCID 178432276、化合物

生成物 1

HCID 178432279HCID 178432279、化合物収率 80%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
61.5 °C

実験手順

Concentrated hydrochloric acid (0.7 ml) was added to a mixture of the crude N-benzhydrylidene-N′-(7-fluoro-2-methyl-1H-benzimidazol-5-yl)-hydrazine (325 mg) and ethanol (0.7 ml). This was stirred at 59 to 64° C. for one hour, and the reaction mixture was cooled to room temperature. Then, the precipitated solid was collected by filtration and dried. Thus, 7-fluoro-2-methyl-1H-benzimidazol-5-yl-hydrazine dihydrochloride (90 mg, 80%) was obtained.

後処理

  1. temperaturethe reaction mixture was cooled to room temperature
  2. filtrationThen, the precipitated solid was collected by filtration
  3. customdried

出典と根拠

ORDレコード
ord-608b887779d1467aacfe3c34274d82e6
出典データセット
uspto-grants-2015_08
特許番号
US09102692B2

関連ノート

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