関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | (Z)-2-Hydroxy Doxepin | HCID 67319009 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | (E)-2-Hydroxy Doxepin | HCID 59023617 | — |
反応手順
A mixture of (Z)-2-Hydroxy-11-(3-dimethylaminopropylidene)-6,11-dihydrodibenzo[b,e]oxepin (2.5 mg, 8.5×10−6 mol) was dissolved in a mixture of hydrochloric acid (1 mL) and methanol (9 mL) and heated at 140° C. (oil bath) for 4 hr. The product was isolated by means of HPLC and evaporation of solvents.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09107898B2 |
|---|
| 出典データセット | uspto-grants-2015_08 |
|---|
| ORD ID | ord-c0db4a8bd81f4d39b30e5697fbdc8eec |
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| 出典メモ | uspto-grants-2015_08 |
|---|
