2,4-Difluoroacetophenone → 1-(2,4-Difluorophenyl)-3-(dimethylamino)prop-2-en-1-one
反応式
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:11])[CH3:10].[CH3:12][N:13]([CH:15](OC)OC)[CH3:14]>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:11])/[CH:10]=[CH:12]/[N:13]([CH3:15])[CH3:14]参加物
3
実験手順
The title compound was prepared in 82% yield from 1-(2,4-difluorophenyl)ethanone and DMF-DMA according to the procedure for the preparation of Example 12, part A. 1H NMR (400 MHz, CDCl3): δ 2.90 (3H, s), 3.11 (3H, s), 5.59-5.62 (1H, m), 6.77-6.83 (1H, m), 6.88-6.93 (m, 1H), 7.75-7.83 (2H, m).
出典と根拠
- ORDレコード
- ord-e2d1a9a75ac5442dace4ac44961f2e77
- 出典データセット
- uspto-grants-2015_08
- 特許番号
- US09107916B2
反応ノート
読み込み中…