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4-Dimethylaminoacetophenone → (2E)-3-(dimethylamino)-1-[4-(dimethylamino)phenyl]prop-2-en-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Dimethylaminoacetophenone | HCID 75037 | — |
| 触媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| 生成物 | (2E)-3-(dimethylamino)-1-[4-(dimethylamino)phenyl]prop-2-en-1-one | HCID 71285027 | 35.8% |
反応手順
A solution of 1-[4-(dimethylamino)phenyl]ethanone (500 mg, 3.1 mmol) in DMF-DMA (10 mL), toluene (10 mL), and AcOH (2 drops), was heated under reflux conditions for 48 h. The solution was concentrated and purified by flash column chromatography (hexanes:EtOAc=8:2˜1:1) to give the title compound (121 mg, 18%) as a yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09107916B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-902f43f21db94618b0be5351002cdefa |
| 出典メモ | uspto-grants-2015_08 |