(2-Chloro-4-methylphenyl)methanol → 2-[5-[(2-Chloro-4-methylphenyl)methoxy]pyrazol-1-yl]pyridine-4-carbonitrile

HRID 514511

反応式

HRID 514511 の反応式
[OH:1][C:2]1[N:6]([C:7]2[CH:12]=[C:11]([C:13]#[N:14])[CH:10]=[CH:9][N:8]=2)[N:5]=[CH:4][CH:3]=1.[Cl:15][C:16]1[CH:21]=[C:20]([CH3:22])[CH:19]=[CH:18][C:17]=1[CH2:23]O>>[Cl:15][C:16]1[CH:21]=[C:20]([CH3:22])[CH:19]=[CH:18][C:17]=1[CH2:23][O:1][C:2]1[N:6]([C:7]2[CH:12]=[C:11]([C:13]#[N:14])[CH:10]=[CH:9][N:8]=2)[N:5]=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 15544016(2-Chloro-4-methylphenyl)methanolHCID 178510213HCID 178510213、化合物

生成物 1

HCID 867256252-[5-[(2-Chloro-4-methylphenyl)methoxy]pyrazol-1-yl]pyridine-4-carbonitrile

実験手順

The title compound was prepared from 2-(5-hydroxy-1H-pyrazol-1-yl)pyridine-4-carbonitrile and (2-chloro-4-methylphenyl)methanol according to the procedure for the preparation of Example 39, part C. 1H NMR (400 MHz, CDCl3): δ 2.35 (3H, s), 5.30 (2H, s), 5.80 (1H, d, J=1.6 Hz), 7.10 (1H, d, J=8.4 Hz), 7.25 (1H, d, J=3.2 Hz), 7.40 (2H, dd, J=1.2 Hz, 5.2 Hz), 7.58 (1H, d, J=2.4 Hz), 8.06 (1H, s), 8.71 (1H, d, J=5.2 Hz). [M+H] Calc'd for C17H13ClN4O, 325. Found, 325.

出典と根拠

ORDレコード
ord-9effeee9dbf440c6928ea2810d5e1d95
出典データセット
uspto-grants-2015_08
特許番号
US09107916B2

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