Hydrochloric Acid → HCID 178513824、化合物

HRID 514677

反応式

HRID 514677 の反応式
O.O.Cl.[OH:4][C:5]1[NH:9][CH:8]=[N:7][C:6]=1[C:10]([NH2:12])=[O:11].Cl.C([O-])=O.[Na+]>>[OH:4][C:5]1[NH:9][CH:8]=[N:7][C:6]=1[C:10]([NH2:12])=[O:11]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 2723810Sodium FormateHCID 178479550HCID 178479550、化合物

生成物 1

HCID 178513824HCID 178513824、化合物収率 100.5%

反応条件

温度
50 °C

実験手順

Under the nitrogen atmosphere, 20.0 g of 5-hydroxy-1H-imidazole-4-carboxamide hydrochloric acid salt dihydrate prepared according to the method of Reference Example 2 was added to 240 mL of 0.45 mol/L hydrochloric acid and dissolved therein by heating to 50° C. At 50° C., 40 mL aqueous solution containing 14.3 g of sodium formate was added dropwise thereto over 33 minutes. The reaction mixture was cooled. The crystal was collected by filtration and then washed with a mixture liquid containing 20 mL of acetone and 40 mL of water followed by 60 mL of acetone to give 12.8 g of 5-hydroxy-1H-imidazole-4-carboxamide.3/4 hydrate as a pale yellow crystal. The infrared absorption spectrum (ATR method) corresponds to that of Example 4.

後処理

  1. dissolutiondissolved
  2. additionwas added dropwise
  3. temperatureThe reaction mixture was cooled
  4. filtrationThe crystal was collected by filtration
  5. washwashed with a mixture liquid
  6. additioncontaining 20 mL of acetone and 40 mL of water

出典と根拠

ORDレコード
ord-46b3f5b3dd64454bb4070a247dba9925
出典データセット
uspto-grants-2015_08
特許番号
US09108928B2

関連ノート

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