Hydrochloric Acid → 3-[(Propan-2-ylsulfonyl)methyl]anilinium chloride

HRID 514704ノート

反応式

HRID 514704 の反応式
[CH3:1][CH:2]([S:4]([CH2:7][C:8]1[CH:9]=[C:10]([NH:14]C(=O)C)[CH:11]=[CH:12][CH:13]=1)(=[O:6])=[O:5])[CH3:3].[ClH:18].C(O)C.C(OCC)(=O)C>C(O)C>[Cl-:18].[CH3:3][CH:2]([S:4]([CH2:7][C:8]1[CH:9]=[C:10]([CH:11]=[CH:12][CH:13]=1)[NH3+:14])(=[O:6])=[O:5])[CH3:1]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 21584252Ethanol ethylacetateHCID 70976422N-{3-[(Propan-2-ylsulfonyl)methyl]phenyl}acetamide

生成物 1

HCID 867296113-[(Propan-2-ylsulfonyl)methyl]anilinium chloride

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of N-{3-[(propan-2-ylsulfonyl)methyl]phenyl}acetamide (5.4 g) in ethanol (29.6 mL) was treated with concentrated hydrochloric acid (35.5 mL) and refluxed for 24 hours. The reaction mixture was condensed to dryness. The title compound (3.5 g) was obtained by crystallization from ethanol/ethyl acetate.

後処理

  1. temperaturerefluxed for 24 hours
  2. customcondensed to dryness

出典と根拠

ORDレコード
ord-dea0212918ad4166a6a1d503b0117750
出典データセット
uspto-grants-2015_08
特許番号
US09108926B2

反応ノート

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