4-Bromophenol → 2-(4-Bromophenoxy)benzonitrile

HRID 51485

反応式

HRID 51485 の反応式
F[C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[Br:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Br:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][C:2]2[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=2[C:4]#[N:5])=[CH:13][CH:12]=1

参加物

5

反応物 3

HCID 78084-BromophenolHCID 11430Potassium CarbonateHCID 678552-Fluorobenzonitrile

生成物 1

HCID 227364352-(4-Bromophenoxy)benzonitrile

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
120 °C

実験手順

A mixture of 2-fluorobenzonitrile (28.8 g), 4-bromophenol (36.9 g), potassium carbonate (58.9 g) and dimethylformamide (30 ml) was heated with stirring under nitrogen at 120° C. for 5 hours. The mixture was allowed to stand overnight at ambient temperature and then partitioned between ethyl acetate and water. The organic layer was separated, washed, dried and evaporated to give an oil which solidified on standing. The solid was triturated with petroleum ether b.p. 40-60° C. and filtered to give 2-(4-bromophenoxy)benzonitrile.

後処理

  1. temperaturewas heated
  2. waitto stand overnight at ambient temperature
  3. custompartitioned between ethyl acetate and water
  4. customThe organic layer was separated
  5. washwashed
  6. customdried
  7. customevaporated
  8. customto give an oil which
  9. customThe solid was triturated with petroleum ether b.p. 40-60° C.
  10. filtrationfiltered

出典と根拠

ORDレコード
ord-55b7fb0c0aa44265ba7561577d290abe
出典データセット
uspto-grants-2004_03
特許番号
US06713474B2

関連ノート

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