1-Bromo-4-[(1S,2R)-2-vinylcyclopropyl]benzene → 1-Bromo-4-[(1r,2s)-2-vinyl-cycloprop-1-yl]benzene

HRID 515053ノート

反応式

HRID 515053 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:10][C@@H:9]2[CH:11]=[CH2:12])=[CH:4][CH:3]=1>CCCCCC>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[CH2:10][C@H:9]2[CH:11]=[CH2:12])=[CH:4][CH:3]=1

参加物

3

反応物 1

HCID 684062521-Bromo-4-[(1S,2R)-2-vinylcyclopropyl]benzene

生成物 1

HCID 692307461-Bromo-4-[(1r,2s)-2-vinyl-cycloprop-1-yl]benzene

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

実験手順

The aldehyde intermediate from Example 29E (2.35 g, 10.44 mmol) was converted to the alkene by the methods outlined in Example 26E, followed by chromatography (100% hexane) provided the title compound. 1H NMR (300 MHz, CDCl3): δ 1.07-1.19 (m, 2H), 1.60-1.71 (m, 1H), 1.83-1.91 (m, 1H), 4.91-4.97 (m, 1H), 5.05-5.14 (m, 1H), 5.45-5.59 (m, 1H), 6.93 (d, J=9 Hz, 2H), 7.36 (d, J=9 Hz, 2H). MS (DCl—NH3) m/z 241 (M+NH4)+.

出典と根拠

ORDレコード
ord-6629aa7d8f9742dc80f0c31f2353da5c
出典データセット
uspto-grants-2015_08
特許番号
US09108948B2

反応ノート

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