Hydrochloric Acid → Acetophenone hydrochloride

HRID 51517ノート

反応式

HRID 51517 の反応式
[C:1]([NH2:5])([CH3:4])([CH3:3])[CH3:2].Br[CH2:7][C:8]([C:10]1[CH:15]=[CH:14][C:13]([O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:12][CH:11]=1)=[O:9].[ClH:23]>CC(O)C>[ClH:23].[O:16]([C:13]1[CH:12]=[CH:11][C:10]([C:8](=[O:9])[CH2:7][NH:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[CH:15][CH:14]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[ClH:23].[C:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(=[O:9])[CH3:7]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 6385Tert-ButylamineHCID 147976752-Bromo-1-(4-phenoxyphenyl)ethan-1-one

生成物 2

HCID 21560873Acetophenone hydrochlorideHCID 22736374HCID 22736374、化合物

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

反応条件

温度
80 °C

実験手順

Tert-butylamine (15 ml) was added with stirring to a solution of 2-bromo-4′-phenoxyacetophenone (12.7 g, prepared by bromination of 4′-phenoxyacetophenone according to Tetrahedron Letters, 1993, 34, 3177) in propan-2-ol and the mixture heated at 80° C. for 3 hours. The mixture was cooled to 0° C. and concentrated hydrochloric acid (10 ml) added. The suspension was stirred at ambient temperature for 18 hours and the solid collected by filtration to give 4′-phenoxy-2-(tert-butylamino)acetophenone hydrochloride (3.75 g), m.p. 210-212° C. butylamino)acetophenone hydrochloride (3.75 g), m.p. 210-212° C.

後処理

  1. temperatureThe mixture was cooled to 0° C.
  2. filtrationthe solid collected by filtration

出典と根拠

ORDレコード
ord-311a6c3b08c242f7adf62979b222fbff
出典データセット
uspto-grants-2004_03
特許番号
US06713474B2

反応ノート

読み込み中…