Sulfuric Acid → 4-Bromo-2,6-diethylbenzoic acid

反応式

[Br:1][C:2]1[CH:20]=[C:19]([CH2:21][CH3:22])[C:5]([C:6](NC2C=CC=C3C=2N=CC=C3)=[O:7])=[C:4]([CH2:23][CH3:24])[CH:3]=1.S(=O)(=O)(O)[OH:26]>>[Br:1][C:2]1[CH:3]=[C:4]([CH2:23][CH3:24])[C:5]([C:6]([OH:7])=[O:26])=[C:19]([CH2:21][CH3:22])[CH:20]=1

参加物

反応物 2

HCID 1118Sulfuric Acid

HCID 86699768HCID 86699768、化合物

生成物 1

HCID 532567664-Bromo-2,6-diethylbenzoic acid収率 56%

反応条件

温度: 120 °C

実験手順

A mixture of 4-bromo-2,6-diethyl-N-quinolin-8-yl-benzamide (2.9 g, 7.6 mmol) in 40% sulphuric acid (15 ml) is heated at 120° C. for 16 h. After completion, the reaction mixture is extracted with ether (2×100 ml) and the combined organic layers are dried over sodium sulfate and concentrated to obtain 4-bromo-2,6-diethyl-benzoic acid (1.1 g, 4.28 mmol, 56%).

後処理

extractionAfter completion, the reaction mixture is extracted with ether (2×100 ml)
dry with materialthe combined organic layers are dried over sodium sulfate
concentrationconcentrated

出典と根拠

ORDレコード: ord-918def4a46ee460c8546069c4ceae6d3
出典データセット: uspto-grants-2015_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09108936B2

反応ノート

読み込み中…

参加物