2-(4-(6-Chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol → Isopropyl 2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate
反応式
[NH2:1][C:2]1[S:3][C:4]([C:7]([O:9][CH:10]([CH3:12])[CH3:11])=[O:8])=[CH:5][N:6]=1.Cl[C:14]1[N:19]=[C:18]([CH3:20])[N:17]=[C:16]([N:21]2[CH2:26][CH2:25][N:24]([CH2:27][CH2:28][OH:29])[CH2:23][CH2:22]2)[CH:15]=1>>[OH:29][CH2:28][CH2:27][N:24]1[CH2:23][CH2:22][N:21]([C:16]2[N:17]=[C:18]([CH3:20])[N:19]=[C:14]([NH:1][C:2]3[S:3][C:4]([C:7]([O:9][CH:10]([CH3:12])[CH3:11])=[O:8])=[CH:5][N:6]=3)[CH:15]=2)[CH2:26][CH2:25]1参加物
3
実験手順
Prepared from isopropyl 2-aminothiazole-5-formate and Compound 4: isopropyl 2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate was obtained (yield: 65.2%).
出典と根拠
- ORDレコード
- ord-fb313e5ebe7040c4831a9caeebc48b67
- 出典データセット
- uspto-grants-2015_08