Carbamic acid, 4-pyridinyl-, phenyl ester → 1-(4-(1-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-yl)phenyl)-3-(pyridin-4-yl)urea

HRID 515338ノート

反応式

HRID 515338 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([C:21]([OH:30])([C:26]([F:29])([F:28])[F:27])[C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[N:31]1[CH:36]=[CH:35][C:34]([NH:37][C:38](=O)[O:39]C2C=CC=CC=2)=[CH:33][CH:32]=1>O1CCOCC1>[F:25][C:22]([F:23])([F:24])[C:21]([C:18]1[CH:19]=[CH:20][C:15]([CH2:14][N:11]2[CH2:12][CH2:13][CH:8]([C:5]3[CH:6]=[CH:7][C:2]([NH:1][C:38]([NH:37][C:34]4[CH:35]=[CH:36][N:31]=[CH:32][CH:33]=4)=[O:39])=[CH:3][CH:4]=3)[CH2:9][CH2:10]2)=[CH:16][CH:17]=1)([OH:30])[C:26]([F:29])([F:27])[F:28]

参加物

4

反応物 2

HCID 11401617Carbamic acid, 4-pyridinyl-, phenyl esterHCID 873035432-(4-((4-(4-Aminophenyl)piperidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

生成物 1

HCID 866709681-(4-(1-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-yl)phenyl)-3-(pyridin-4-yl)urea

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

反応条件

温度
100 °C

実験手順

Reaction 2: A mixture of 2-(4-((4-(4-aminophenyl)piperidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (0.925 mmol, 400 mg) and phenyl pyridin-4-ylcarbamate (1.388 mmol, 297 mg) in dioxane was heated in a reactivial at 100° C. (heating block temperature) for 48 hours.

後処理

  1. customReaction 2
  2. temperature(heating block temperature) for 48 hours

出典と根拠

ORDレコード
ord-f81a54b7a58847d2ac05949c4815432e
出典データセット
uspto-grants-2015_08
特許番号
US09108939B2

反応ノート

読み込み中…