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Reserpine → 4-Bromo-2-methyl-1-phenoxybenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Reserpine | HCID 5770 | — |
| 反応物 | 4-Bromo-2-methylphenol | HCID 16896 | — |
| 反応物 | Phenylboronic Acid | HCID 66827 | — |
| 反応物 | 4-Bromo-2-chloro-1-phenoxybenzene | HCID 22736309 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 4-Bromo-2-methyl-1-phenoxybenzene | HCID 22736253 | 35% |
反応手順
The title compound was prepared in a 35% yield from 4-bromo-2-methylphenol and phenyl boronic acid in a manner similar to that described for the preparation of 4-bromo-2-chloro-1-phenoxybenzene: 1H NMR (DMSO-d6, 400 MHz) δ 7.54(s, 1H), 7.35(m, 3H), 7.12(t, 1H), 6.93(d, 2H), 6.82(d, 2H), 2.18(s, 3H); RP-HPLC (Hypersil HS, 5 μm, 100 A, 4.6×250 mm; 25%-100% acetonitrile—0.05 M ammonium acetate over 10 min, 1 mmin) tr 14.25min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06713474B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-61cf25a4cfa74d5ebe507117971a32dd |
| 出典メモ | uspto-grants-2004_03 |