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1,3-Benzodioxole-5-carboxaldehyde, 6-bromo- → 6-[4-(Ethoxycarbonyl)-1-methyl-5-trifluoromethyl-1H-pyrrol-2-yl]-1,3-benzodioxole-5-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,3-Benzodioxole-5-carboxaldehyde, 6-bromo- | HCID 95062 | — |
| 反応物 | Ethyl 2-methyl-3-pyrrolecarboxylate | HCID 136747 | — |
| 反応物 | 2-Bromo-4-chlorobenzaldehyde | HCID 13154710 | — |
| 反応物 | ethyl 2-(trifluoromethyl)-1H-pyrrole-3-carboxylate | HCID 85684081 | — |
| 生成物 | 6-[4-(Ethoxycarbonyl)-1-methyl-5-trifluoromethyl-1H-pyrrol-2-yl]-1,3-benzodioxole-5-carboxylic acid | HCID 117833890 | — |
反応手順
The procedure is in accordance with the process of Preparation 1, replacing in Step A the ethyl 2-methyl-1H-pyrrole-3-carboxylate by ethyl 2-(trifluoromethyl)-1H-pyrrole-3-carboxylate and also the 2-bromo-4-chlorobenzaldehyde used in Step B by 6-bromo-1,3-benzodioxole-5-carbaldehyde.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09108983B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-580f8210768c429e9e30116492270c94 |
| 出典メモ | uspto-grants-2015_08 |