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Phenol → 4-Bromo-2-phenoxybenzaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenol | HCID 996 | — |
| 反応物 | Reserpine | HCID 5770 | — |
| 反応物 | 5-Bromo-2-fluorobenzaldehyde | HCID 736327 | — |
| 反応物 | 2-(3-Bromophenoxy)benzonitrile | HCID 28602353 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 4-Bromo-2-phenoxybenzaldehyde | HCID 16413429 | 46% |
反応手順
The title compound was prepared in a 46% yield from 5-bromo-2-fluoro-benzaldehyde and phenol in a manner similar to that described for the preparation of 5-bromo-phenoxybenzonitrile: 1H NMR (DMSO-d6, 400 MHz) δ 10.32(s, 1H), 7.92(s, 1H), 7.81(d, 1H), 7.46(t, 2H), 7.27(t, 1H), 7.18(d, 2H), 6.90(d, 1H) RP-HPLC (Hypersil HS, 5 μm, 100 A 4.6×250 mm; 25%-100% acetonitrile—0.05 M ammonium acetate over 10 min, 1 ml/min) tr 13.08 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06713474B2 |
| 出典データセット | uspto-grants-2004_03 |
| ORD ID | ord-34160c193bba4f8993363aa30d6abc90 |
| 出典メモ | uspto-grants-2004_03 |