Ammonia → HCID 117833822、化合物

HRID 515923ノート

反応式

HRID 515923 の反応式
[Br:1][C:2]1[CH:11]=[C:10]([CH2:12]Br)[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[NH3:14]>CO>[NH2:14][CH2:12][C:10]1[CH:9]=[CH:8][C:3]([C:4]([O:6][CH3:7])=[O:5])=[C:2]([Br:1])[CH:11]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 19806367Methyl 2-bromo-4-(bromomethyl)benzoate

生成物 1

HCID 117833822HCID 117833822、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

A solution of methyl 2-bromo-4-(bromomethyl)benzoate (4.57 g; 14.84 mmol) in 50 mL of methanol is added dropwise to a well-stirred solution of ammonia in methanol (7M; 315 mL) at ambient temperature, and the solution is then stirred for 3 hours. All the solvents are evaporated off and the residue is purified by chromatography over silica gel using dichloromethane-methanol as eluants to yield the title compound.

後処理

  1. customAll the solvents are evaporated off
  2. customthe residue is purified by chromatography over silica gel

出典と根拠

ORDレコード
ord-c84466578b514f35b20262e291c424d9
出典データセット
uspto-grants-2015_08
特許番号
US09108983B2

反応ノート

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