Ammonia → HCID 89650994、化合物
反応式
C([O:9][C@H:10]1[C@:14]([F:16])([CH3:15])[C@H:13]([N:17]2[CH:22]=[CH:21][C:20](=[O:23])[NH:19][C:18]2=[O:24])[O:12][C@@:11]1([F:34])[CH2:25]C(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1.N.C[OH:37]>>[F:16][C@:14]1([CH3:15])[C@H:10]([OH:9])[C@@:11]([F:34])([CH2:25][OH:37])[O:12][C@H:13]1[N:17]1[CH:22]=[CH:21][C:20](=[O:23])[NH:19][C:18]1=[O:24]参加物
4
実験手順
Chiral (2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,4-difluor-O-2-benzoylmethyl-4-methyl-tetrahydrofuran-3-yl benzoate (0.34 g, 0.7 mmol) was dissolved into methanol, and a solution of ammonia in methanol (7 N, 20 mL) was added. The reaction mixture was stirred at room temperature for overnight. The mixture was concentrated, and the residue was purified by silica gel column chromatography (DCM:MeOH=20:1) and pre-HPLC to afford the title compound as a white solid (0.074 g, 38%).