Hydrazine, 1-naphthalenyl- → 3-(4-Bromo-phenyl)-1,5-di-naphthalen-1-yl-1H-[1,2,4]triazole

HRID 516496

反応式

HRID 516496 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[N:12][C:13]([C:15]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH:18]=[CH:17][CH:16]=2)=O)OCC)=[CH:4][CH:3]=1.[C:25]1([NH:35][NH2:36])[C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH:28]=[CH:27][CH:26]=1>C(Cl)(Cl)(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]=[C:13]([C:15]3[C:24]4[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=4)[CH:18]=[CH:17][CH:16]=3)[N:35]([C:25]3[C:34]4[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=4)[CH:28]=[CH:27][CH:26]=3)[N:36]=2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 75240Hydrazine, 1-naphthalenyl-HCID 57610336Naphthalene-1-carboxylic acid 1-(4-bromo-phenyl)-1-ethoxy-methylideneamide

生成物 1

HCID 576103533-(4-Bromo-phenyl)-1,5-di-naphthalen-1-yl-1H-[1,2,4]triazole

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

反応条件

温度
25 °C

実験手順

The compound obtained in step A) (1.0 g, 0.026 mol) and 1-naphthyl hydrazine (0.45 g, 0.028 mol) is dissolved in CCl4 (15 ml) and stirred for 10 hours at 25° C. under a nitrogen atmosphere. The reaction mixture is stirred for 12 hours and filtered to remove traces of insoluble particles. The CCl4 solution is then concentrated and a few drops of methanol are added to the residue, wherein a brownish solid is obtained (Yield=0.7 g (56%)).

後処理

  1. stirringThe reaction mixture is stirred for 12 hours
  2. filtrationfiltered
  3. customto remove traces of insoluble particles
  4. concentrationThe CCl4 solution is then concentrated
  5. additiona few drops of methanol are added to the residue, wherein a brownish solid
  6. customis obtained (Yield=0.7 g (56%))

出典と根拠

ORDレコード
ord-d7c2db3732134b1683088925a9ff0fc8
出典データセット
uspto-grants-2015_08
特許番号
US09113536B2

関連ノート

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