Chlorosuccinimide → 1-butyl-3-chloro-4-hydroxy-2(1H)-Pyridinone

HRID 516621ノート

反応式

HRID 516621 の反応式
[Cl:1]N1C(=O)CCC1=O.[CH2:9]([N:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][C:14]1=[O:20])[CH2:10][CH2:11][CH3:12]>CN(C=O)C>[CH2:9]([N:13]1[CH:18]=[CH:17][C:16]([OH:19])=[C:15]([Cl:1])[C:14]1=[O:20])[CH2:10][CH2:11][CH3:12]

参加物

4

反応物 2

HCID 31398ChlorosuccinimideHCID 594970761-butyl-4-hydroxy-1H-pyridine-2-one

生成物 1

HCID 594970741-butyl-3-chloro-4-hydroxy-2(1H)-Pyridinone収率 83%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

N-Chlorosuccinimide (1.6 g, 11.96 mmol) was added to a solution of intermediate D5 (2.0 g, 11.96 mmol) in DMF (30 ml). The reaction was stirred at room temperature overnight and then it was concentrated in vacuo. The crude product was purified by column chromatography (silica gel; 0-5% methanol/DCM as eluent) to yield intermediate D8 (2.0 g, 83%).

後処理

  1. concentrationit was concentrated in vacuo
  2. customThe crude product was purified by column chromatography (silica gel; 0-5% methanol/DCM as eluent)

出典と根拠

ORDレコード
ord-d1a09d08328e43e1a0428aa54f626a7a
出典データセット
uspto-grants-2015_08
特許番号
US09114138B2

反応ノート

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