Triphenylphosphine → Ethyl 2-(3-(2,6-Dimethoxybenzyloxy)phenyl)acetate

関与物質

役割	名称	HCID	仕込み量
反応物	Triphenylphosphine	HCID 11776	—
反応物	Diisopropyl diazene-1,2-dicarboxylate	HCID 75555	—
反応物	Ethyl (3-Hydroxyphenyl)acetate	HCID 572437	—
反応物	(2,6-Dimethoxyphenyl)methanol	HCID 2776839	—
溶媒	Diethyl Ether	HCID 3283	—
溶媒	Tetrahydrofuran	HCID 8028	—
生成物	Ethyl 2-(3-(2,6-Dimethoxybenzyloxy)phenyl)acetate	HCID 66875196	—

反応手順

A solution of 2,6-Dimethoxylbenzyl alcohol (3.33 g, 19.8 mmol) and diisopropyl azodicarboxylate (DIAD, 4.36 g, 21.6 mmol) in THF (30 ml) was added drop wise to a solution of Ethyl 2-(3-hydroxyphenyl)acetate (4 g, 22.2 mmol) and triphenylphosphine (5.66 g, 21.6 mmol) in THF (80 ml). The reaction mixture was stirred at room temperature for 8 hours, diluted with ether and washed with water and brine. The organic layer was dried over Na2SO4, filtered, concentrated, and purified by flash chromatography on a silica gel column (hex:ethyl acetate 4:1) to give the title compound.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US09115072B2
出典データセット	uspto-grants-2015_08
ORD ID	ord-3ded422a4c70476abf6b3ac56ed8b572
出典メモ	uspto-grants-2015_08