戻る
化工社化工社 化学情報印刷レポート · 研究参考用
HRID 517036作成日：2026年10月26日

3-Chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid → 3-Chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [3-((4R,5R)-2-amino-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide

https://huagongshe.com/reaction/517036

反応式

関与物質

役割名称HCID仕込み量
反応物3-Chloro-5-(trifluoromethyl)pyridine-2-carboxylic acidHCID 2821908—
反応物(4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamineHCID 86672004—
生成物3-Chloro-5-trifluoromethyl-pyridine-2-carboxylic acid [3-((4R,5R)-2-amino-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amideHCID 66558686—

反応手順

The condensation of (4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate A8.2) and 3-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid (CAS 80194-68-9) following procedure I yielded the title compound as a white foam. MS (ISP): m/z=449.1 [M+H]+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09115098B2
出典データセットuspto-grants-2015_08
ORD IDord-505a502f00dc4d9aa17f8857c75751ed
出典メモuspto-grants-2015_08