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1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid → 2-Methyl-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [3-((4R,5R)-2-amino-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid | HCID 606540 | — |
| 反応物 | (4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine | HCID 86672004 | — |
| 生成物 | 2-Methyl-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [3-((4R,5R)-2-amino-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide | HCID 66558854 | — |
反応手順
The condensation of (4R,5R)-4-(5-amino-2-fluoro-phenyl)-5-fluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate A8.2) and 2-methyl-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (CAS 128694-63-3) following procedure I yielded the title compound as a white solid. MS (ISP): m/z=418.3 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09115098B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-e9894cafe3f645dfa2e6ee506bec4a21 |
| 出典メモ | uspto-grants-2015_08 |