Diethyl Ether → 7-(4-(Trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

HRID 517103

反応式

HRID 517103 の反応式
[F:1][C:2]([F:27])([F:26])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:18]=[C:17]3[C:12]([CH2:13][CH2:14][N:15](C(OC(C)(C)C)=O)[CH2:16]3)=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.O1CCOCC1.C(OCC)C.C(Cl)[Cl:40]>>[ClH:40].[F:27][C:2]([F:1])([F:26])[C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:18]=[C:17]3[C:12]([CH2:13][CH2:14][NH:15][CH2:16]3)=[CH:11][CH:10]=2)=[CH:7][CH:8]=1

参加物

5

反応物 4

HCID 3283Diethyl EtherHCID 6344DichloromethaneHCID 312751,4-DioxaneHCID 70974981tert-Butyl 7-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

生成物 1

HCID 709747087-(4-(Trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

実験手順

To a solution of tert-butyl 7-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate (1.4 g, 3.7 mmol) in DCM (3 was added 4.0M HO in dioxane (4.6 mL, 18.56 mmol) and stirred at rt for 3 h. Diethylether (200 mL) was then added and the mixture was stirred at rt for 30 min and then filtered and washed with diethylether and dried to give the title compound (1.3 grams).

後処理

  1. stirringthe mixture was stirred at rt for 30 min
  2. filtrationfiltered
  3. washwashed with diethylether
  4. customdried

出典と根拠

ORDレコード
ord-4cefd45676d74f3f9c689da47a8482fb
出典データセット
uspto-grants-2015_08
特許番号
US09115096B2

関連ノート

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