Allylamine → Tert-butyl 2-[(prop-2-en-1-yl)amino]acetate

HRID 517337ノート

反応式

HRID 517337 の反応式
[CH2:1]([NH2:4])[CH:2]=[CH2:3].[C:5]([O:9][C:10](=[O:13])[CH2:11]Br)([CH3:8])([CH3:7])[CH3:6]>ClCCl>[C:5]([O:9][C:10](=[O:13])[CH2:11][NH:4][CH2:1][CH:2]=[CH2:3])([CH3:8])([CH3:7])[CH3:6]

参加物

4

反応物 2

HCID 7853AllylamineHCID 79177tert-Butyl bromoacetate

生成物 1

HCID 19959470Tert-butyl 2-[(prop-2-en-1-yl)amino]acetate収率 100%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

Allylamine (10 mL, 0.13 mol) was cooled to 0° C., and a solution of bromoacetic acid tert-butyl ester (1.0 mL, 6.7 mmol) in dichloromethane (10 mL) was slowly added. After stirring at 0° C. for 3 hours, the reaction mixture was concentrated under reduced pressure. The obtained residue was dissolved in diethyl ether, washed successively with saturated aqueous sodium hydrogen carbonate and saturated brine, and dried over anhydrous sodium sulfate. The obtained solution was concentrated under reduced pressure to give the title compound as a yellow liquid (1.15 g, 6.7 mmol, 99%).

後処理

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. dissolutionThe obtained residue was dissolved in diethyl ether
  3. washwashed successively with saturated aqueous sodium hydrogen carbonate and saturated brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. concentrationThe obtained solution was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-471c952cd846495092a22e16792652ce
出典データセット
uspto-grants-2015_08
特許番号
US09115107B2

反応ノート

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