Propionic Acid → (E)-5-(4-ethoxycarbonyl-2-methylbut-1-enyl)furan-2-carboxylic acid benzyl ester
反応式
[CH2:1]([O:8][C:9]([C:11]1[O:12][C:13]([CH:16](O)[C:17]([CH3:19])=[CH2:18])=[CH:14][CH:15]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:21](OCC)([O:25][CH2:26][CH3:27])[O:22]CC.[C:31](O)(=O)CC>>[CH2:1]([O:8][C:9]([C:11]1[O:12][C:13](/[CH:16]=[C:17](\[CH3:19])/[CH2:18][CH2:31][C:21]([O:25][CH2:26][CH3:27])=[O:22])=[CH:14][CH:15]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
反応条件
- 温度
- 138 °C
実験手順
To the compound (332 mg, 1.23 mmol) obtained in step 1 were added triethyl orthoformate (5.0 mL, 27 mmol) and propionic acid (0.020 mL, 0.27 mmol), and the mixture was stirred at 138° C. overnight. The reaction mixture was purified by silica gel column chromatography (hexane/ethyl acetate=90/10) to give the title compound (149 mg, 0.435 mmol, 35%).
後処理
- customThe reaction mixture was purified by silica gel column chromatography (hexane/ethyl acetate=90/10)
出典と根拠
- ORDレコード
- ord-df7ef03fdea44cd89bafe7bbb6342bca
- 出典データセット
- uspto-grants-2015_08
- 特許番号
- US09115107B2
反応ノート
読み込み中…