Propionic Acid → 5-[5-(Benzyloxycarbonyl)furan-2-yl]-4-tert-butoxycarbonyl-4-pentenoic acid ethyl ester
反応式
[C:1]([O:5][C:6](=[O:26])[C:7]([CH:9]([C:11]1[O:12][C:13]([C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])=[CH:14][CH:15]=1)O)=[CH2:8])([CH3:4])([CH3:3])[CH3:2].[CH:27]([O-:32])([O-])[O:28][CH2:29][CH3:30].[C:33](O)(=O)CC>>[CH2:29]([O:28][C:27](=[O:32])[CH2:33][CH2:8][C:7]([C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:26])=[CH:9][C:11]1[O:12][C:13]([C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])=[CH:14][CH:15]=1)[CH3:30]参加物
4
反応条件
- 温度
- 138 °C
実験手順
2-{[5-(Benzyloxycarbonyl)furan-2-yl](hydroxy)methyl}prop-2-enoic acid tert-butyl ester (90 mg, 0.25 mmol) was dissolved in ethyl orthoformate (2.0 mL, 10.9 mmol), propanoic acid (8 mg, 0.10 mmol) was added, and the mixture was stirred at 138° C. for 5 hours. The mixture was purified by silica gel column chromatography to give the title compound.
後処理
- customThe mixture was purified by silica gel column chromatography
出典と根拠
- ORDレコード
- ord-89259d6f251d48c1ba176b161723cf51
- 出典データセット
- uspto-grants-2015_08
- 特許番号
- US09115107B2
反応ノート
読み込み中…