4-Bromophenyl isocyanate → 4-[3-(4-Bromo-phenyl)-ureido]-N,N-dimethyl-benzamide

HRID 517417ノート

反応式

HRID 517417 の反応式
[NH2:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([N:8]([CH3:10])[CH3:9])=[O:7])=[CH:4][CH:3]=1.[Br:13][C:14]1[CH:19]=[CH:18][C:17]([N:20]=[C:21]=[O:22])=[CH:16][CH:15]=1>C(Cl)Cl>[Br:13][C:14]1[CH:19]=[CH:18][C:17]([NH:20][C:21](=[O:22])[NH:1][C:2]2[CH:12]=[CH:11][C:5]([C:6]([N:8]([CH3:10])[CH3:9])=[O:7])=[CH:4][CH:3]=2)=[CH:16][CH:15]=1

参加物

4

反応物 2

HCID 756094-Bromophenyl isocyanateHCID 2355274-Amino-N,N-dimethylbenzamide

生成物 1

HCID 689172644-[3-(4-Bromo-phenyl)-ureido]-N,N-dimethyl-benzamide収率 88.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 4-amino-N,N-dimethyl-benzamide (3.5 g, 0.0213 mol), TEA (2.15 g, 0.0213 mol) in DCM (50 mL) was added 4-bromophenyl isocyanate (5.07 g, 0.0256 mol). The reaction mixture was stirred at room temperature for 12 h. The white solid was obtained and was filtered and dried to afford the title compound [6.8 g, 88%]; LC-MS (ESI): Calculated mass: 361.0; Observed mass: 362.0 [M+H]+ (RT: 0.17 min).

後処理

  1. customThe white solid was obtained
  2. filtrationwas filtered
  3. customdried

出典と根拠

ORDレコード
ord-051ee5daeb974aa1b4af6dc36c889d69
出典データセット
uspto-grants-2015_08
特許番号
US09115092B2

反応ノート

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