関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Acetamide, N-(3-bromophenyl)-2-(hydroxyimino)- | HCID 6739944 | — |
| 生成物 | 1H-Indole-2,3-dione, 6-bromo- | HCID 95716 | 98% |
反応手順
To the concentrated sulfuric acid (275 mL) at 50° C. was added N-(3-Bromo-phenyl)-2-hydroxyimino-acetamide (55 g, 0.2272 mol). The temperature was raised to 90° C. and maintained for 3 h. The reaction mixture was added to ice cold water to get yellow precipitate. The precipitate was filtered and dried to get the title compound as a yellow solid [50 g, 98%]. This material was taken to the next step without any further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09115092B2 |
|---|
| 出典データセット | uspto-grants-2015_08 |
|---|
| ORD ID | ord-097cadf1ee1e402d8af8573733d12e98 |
|---|
| 出典メモ | uspto-grants-2015_08 |
|---|
