2,2,2-Trichloroethyl chloroformate → {5-[7-(3-Methanesulfonyl-phenyl)-4-morpholin-4-yl-quinazolin-2-yl]-pyridine-2-yl}-carbamic acid 2,2,2-trichloroethyl ester

HRID 517445ノート

反応式

HRID 517445 の反応式
[CH3:1][S:2]([C:5]1[CH:6]=[C:7]([C:11]2[CH:20]=[C:19]3[C:14]([C:15]([N:28]4[CH2:33][CH2:32][O:31][CH2:30][CH2:29]4)=[N:16][C:17]([C:21]4[CH:22]=[CH:23][C:24]([NH2:27])=[N:25][CH:26]=4)=[N:18]3)=[CH:13][CH:12]=2)[CH:8]=[CH:9][CH:10]=1)(=[O:4])=[O:3].[Cl:34][C:35]([Cl:42])([Cl:41])[CH2:36][O:37][C:38](Cl)=[O:39]>C(Cl)Cl>[Cl:34][C:35]([Cl:42])([Cl:41])[CH2:36][O:37][C:38](=[O:39])[NH:27][C:24]1[CH:23]=[CH:22][C:21]([C:17]2[N:16]=[C:15]([N:28]3[CH2:33][CH2:32][O:31][CH2:30][CH2:29]3)[C:14]3[C:19](=[CH:20][C:11]([C:7]4[CH:8]=[CH:9][CH:10]=[C:5]([S:2]([CH3:1])(=[O:3])=[O:4])[CH:6]=4)=[CH:12][CH:13]=3)[N:18]=2)=[CH:26][N:25]=1

参加物

4

反応物 2

HCID 870632,2,2-Trichloroethyl chloroformateHCID 675144285-[7-(3-Methanesulfonyl-phenyl)-4-morpholin-4-yl-quinazolin-2-yl]-pyridin-2-ylamine

生成物 1

HCID 67514937{5-[7-(3-Methanesulfonyl-phenyl)-4-morpholin-4-yl-quinazolin-2-yl]-pyridine-2-yl}-carbamic acid 2,2,2-trichloroethyl ester収率 57,934.398%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a cooled solution (0° C.) of 5-[7-(3-methanesulfonyl-phenyl)-4-morpholin-4-yl-quinazolin-2-yl]-pyridin-2-ylamine (125 mg, 0.000271 mmol) in DCM (4 mL) was added 2,2,2-trichloroethylchloroformate (0.054 mL, 0.0004 mol) and TEA (0.056 mL, 0.0004 mol). The reaction mixture was allowed to stir at ambient temperature for 5 h. The volatiles were evaporated to get the crude product (100 mg). This material was taken to the next step without further purification.

後処理

  1. customThe volatiles were evaporated

出典と根拠

ORDレコード
ord-5fc9d2e8e0a94ff4931121a2cab45b40
出典データセット
uspto-grants-2015_08
特許番号
US09115092B2

反応ノート

読み込み中…